宁约瑟，男，河南洛阳人，研究员，博士生导师。国家自然科学基金优秀青年基金获得者，入选农业农村部“神农青年英才”和“杰出青年农业科学家”；获得中国农学会“青年科技奖”；被遴选为中国植物病理学会会士；获得第七届卫志明青年创新奖；第一完成人获得中国农业科学院科学技术成果奖。现任国家农业生物安全中心副主任、植保生物技术中心主任、作物病原生物功能基因组研究创新团队首席科学家。兼任中国农学会理事、中国植物保护学会理事和中国植物病理学会副秘书长。
2005年获河南农业大学农学专业学士学位，2011年获湖南农业大学作物遗传育种专业博士学位，2006年-2010年在教育部博士生访学计划资助下在中国科学院遗传与发育生物学研究所遗传学专业进行联合培养，2010年-2011年在美国俄亥俄州立大学植物病理系做访问博士研究生。2011年至今在中国农业科学院植物保护研究所植物病虫害综合治理全国重点实验室工作；2014年2月-2014年5月在美国俄亥俄州立大学植物病理系做访问学者。
主要从事水稻与稻瘟菌互作和水稻抗病性遗传学研究。先后主持国家自然科学基金优秀青年科学基金和国家重点研发计划等国家级课题7项。系统解析稻瘟菌效应蛋白与水稻靶标蛋白的互作机制，创制植物中首个E3泛素连接酶鉴定体系，揭示水稻核心E3泛素连接酶介导的抗稻瘟病新机制，为创制稻瘟病综合防控策略奠定了重要基础。研究结果先后发表SCI收录论文80余篇，总被引频次5300余次，H指数42。以第一/通讯作者（含共同）在Developmental Cell、Science Advances、Nature Plants、Genome Biology、Plant Cell、和Molecular Plant等杂志发表高水平SCI论文45篇。其中2项研究被Faculty Opinions推荐为新发现，8项研究分别被Trends in Plant Science、Current Biology、Nature Food和Science Bulletin和Science China Life Sciences杂志专题评论。受邀在Annual Review of Plant Biology和Trends in Plant Science等杂志发表综述和评论文章。受邀在国际植物与微生物互作大会（IS-MPMI XVIII Congress）、国际稻瘟病大会（International Rice Blast Conference）和国际动植物基因组大会（Plant & Animal Genome XXV Conference）等国际会议上做特邀报告。担任Journal of Integrative Plant Biology和BMC Plant Biology等SCI收录期刊编委。
E-mail: ningyuese@caas.cn
Website: https://www.researchgate.net/profile/Yuese_Ning
代表性论文(#共同第一作者，*通讯作者）：
1. Hui Tao, Ruyi Wang, Feng He, Chongyang Zhang, Su Jiang, Min Wang, Xiao Xu, Jisong Wang, Xiaoman You, Dan Wang, Jiangbo Fan, Hailong Guo, Kabin Xie, Guo-Liang Wang & Yuese Ning (*). Phosphorylation and ubiquitination synergistically promote the degradation of OsRbohB to modulate rice immunity. Plant Cell. DOI: 10.1093/plcell/koaf276, 2025
2. Xinyi Hou (#), Xiaoman You (#), Xudong Mi, Xuanda Huang, Huiting Hu, Jisong Wang, Feng He, Ruyi Wang, Shutong Wang (*), Yuese Ning (*). Balancing rice blast resistance and growth through suppression of the E3 ubiquitin ligase OsRING80. Plant Physiology. DOI: 10.1093/plphys/kiaf620, 2025
3. Feng He , Hui Tao, Ruyi Wang, Jinling Liu, Zeyun Hao, Debao Wang, Xuetao Shi, Fan Zhang, Jiawei Long, Hao Zhang, Xiao Yang, Mengchao Qin, Shasha Peng, Chongyang Zhang, Xiaoman You, Hailong Guo, Fangfang Li, Caiji Gao, Yule Liu, Guo-Liang Wang, and Yuese Ning (*). OsATG1 and OsATG8 exhibit autophagy-independent functions to oppositely regulate ROP GTPase-mediated plant immunity in rice. Molecular Plant.18:1472–1489, 2025
Highlighted with a Research Highlight article in Molecular Plant https://doi.org/10.1016/j.molp.2025.08.016
4. Feng He (#), Min Wang (#), Su Jiang, Dan Wang, Ruyi Wang, Guo-Liang Wang, Hui Tao (*), and Yuese Ning (*). Mutation of OsJAC1 enhances rice resistance to diverse diseases without yield penalty. The Crop Journal. 13(5): 1637-1641, 2025
5. Xiaoman You (#), Jisong Wang (#), Guo-Liang Wang (*), and Yuese Ning (*). Disruption of E3 ubiquitin ligase confers disease resistance. Trends in Plant Science. 30(11): 1183-1185, 2025
6. Zeyu Wang , Ruyi Wang, Yuese Ning (*), and Jie Zhang (*). Plant pathology: The infection source of rice false smut fungi. Current Biology. 35(14): R718-R720, 2025
7. Ruyi Wang, Zhiyuan Ji, Yanjun Kou, Xiuling Yang, Wenkun Huang, Zongtao Sun, Shimin Zuo, Zhiqiang Li, Yehui Xiong, Yiwen Deng, Xueping Zhou, Guo-Liang Wang, Jie Liu (*), and Yuese Ning (*). Occurrence and integrated control of major rice diseases in China. New Plant Protection. 2: e70004, 2025
8. Zeyun Hao (#), Xiao Xu (#), Guo-Liang Wang, Ruyi Wang (*), and Yuese Ning (*). E3 ubiquitin ligases at the frontline of antiviral defence. Nature Plants. 11(6): 1096-1097, 2025
9. Chongyang Zhang (#), Liang Fang (#), Feng He, Xiaoman You, Min Wang, Tianxiao Zhao, Yanyan Hou, Ning Xiao, Aihong Li, Jian Yang, Jue Ruan, Frédéric Francis, Guo-Liang Wang, Ruyi Wang (*), and Yuese Ning (*). Ubiquitination of OsCSN5 by OsPUB45 activates immunity by modulating the OsCUL3a-OsNPR1 module. Science Advances. 11(1): eadr2441, 2025
Highlighted with a Research Highlight article in Science China. Life Sciences https://doi.org/10.1007/s11427-025-2998-6
10. Hui Tao, Ning Xiao, Ruyi Wang, Feng He, Yue Cai, Su Jiang, Min Wang, Dan Wang, Huamin Chen, Xiaoman You, Aihong Li, Guo-Liang Wang, and Yuese Ning (*). Development of elite rice with broad-spectrum resistance through pyramiding of key resistance gene and simultaneously editing multiple susceptibility genes. Journal of Integrative Plant Biology. 67(7): 1691-1693, 2025
11. Yuese Ning (*)and Zhiyong Liu (*). Crop disease resistance: Genes, mechanisms, and breeding. The Crop Journal. 13(1): 3-4, 2025
12. Xiao Xu(#), Xuetao Shi(#), Xiaoman You, Zeyun Hao, Ruyi Wang, Min Wang, Feng He, Shasha Peng, Hui Tao, Zheng Liu, Jisong Wang, Chongyang Zhang, Qin Feng, Weixun Wu, Guo-Liang Wang, and Yuese Ning (*). A pair of E3 ubiquitin ligases control immunity and flowering by targeting different ELF3 proteins in rice. Developmental Cell. 59(20): 2731-2744, 2024
Highlighted with a Research Highlight article in Science China. Life Sciences https://doi.org/10.1007/s11427-024-2863-6
13. Chongyang Zhang, Hong Fang, Jisong Wang, Hui Tao, Debao Wang, Mengchao Qin, Feng He, Ruyi Wang, Guo-Liang Wang, and Yuese Ning (*). The rice E3 ubiquitin ligase-transcription factor module targets two trypsin inhibitors to enhance broad-spectrum disease resistance. Developmental Cell. 59(15): 2017-2033, 2024
Highlighted with a Research Highlight article in Science China. Life Sciences https://doi.org/10.1007/s11427-025-3040-7
14. Xiaoman You, Shanshan Zhu, Haowen Sheng, Zheng Liu, Dan Wang, Min Wang, Xiao Xu, Feng He, Hong Fang, Fan Zhang, Debao Wang, Zeyun Hao, Ruyi Wang, Yinghui Xiao, Jianmin Wan, Guo-Liang Wang, and Yuese Ning (*). The rice peroxisomal receptor PEX5 negatively regulates resistance to rice blast fungus Magnaporthe oryzae. Cell Reports. 42(10):113315, 2023
Recommended in Faculty Opinions as New Finding and Good for Teaching
15. Ning Xiao(#), Yunyu Wu(#), Xiaoxiang Zhang(#), Zeyun Hao(#), Zichun Chen, Zefeng Yang,Yue Cai1, Ruyi Wang, Ling Yu, Zhiping Wang, Yue Lu, Wei Shi, Cunhong Pan, Yuhong Li, Changhai Zhou, Jianju Liu, Niansheng Huang, Guangqing Liu, Hongjuan Ji, Shuhao Zhu, Shuai Fang, Yuese Ning (*) and Aihong Li (*). Pijx confers broad-spectrum seedling and panicle blast resistance by promoting the degradation of ATP β subunit and OsRbohC-mediated ROS burst in rice. Molecular Plant.16:1832–1846, 2023
16. Wang Ruyi, Guo-Liang Wang (*) and Yuese Ning (*).Harnessing nanobodies to expand the recognition spectrum of plant NLRs for diverse pathogens. aBIOTECH. 4: 272-276, 2023
17. Xiaoman You, Yuese Ning (*), Guo-Liang Wang (*). Editing a rice CDP-DAG synthase confers broad-spectrum resistance. Trends in Plant Science. 28:1344-1346, 2023
17. Fan Zhang (#), Min Wang (#), Guo-Liang Wang, Yuese Ning(*), Ruyi Wang (*). Insights into Metabolite Biosynthesis and Regulation in Rice Immune Signaling. Trends in Microbiology. 31: 225-228, 2023
19. Fan Zhang, Hong Fang, Min Wang, Feng He, Hui Tao, Ruyi Wang, Jiawei Long, Jiyang Wang, Guo-Liang Wang (*),Yuese Ning (*). APIP5 functions as a transcription factor and an RNA-binding protein to modulate cell death and immunity in rice. Nucleic Acids Research. 50: 5064–5079, 2022
Highlighted with a Research Highlight article in Trends in Plant Science
https://doi.org/10.1016/j.tplants.2022.08.001
20. Zeyun Hao (#), Jinfu Tian (#), Hong Fang (#), Liang Fang, Xiao Xu, Feng He, Shaoya Li, Wenya Xie, Qiang Du, Xiaoman You, Debao Wang, Qiuhong Chen, Ruyi Wang, Shimin Zuo, Meng Yuan, Guo-Liang Wang, Lanqin Xia (*), Yuese Ning (*). A VQ-motif- containing protein fine-tunes rice immunity and growth by a hierarchical regulatory mechanism. Cell Reports. 40: 111235, 2022
21. Ruyi Wang (#), Xiaoman You (#), Chongyang Zhang (#), Hong Fang (#), Min Wang, Fan Zhang, Houxiang Kang, Xiao Xu, Zheng Liu, Jiyang Wang, Qingzhen Zhao, Xuli Wang, Zeyun Hao, Feng He, Hui Tao, Debao Wang, Jisong Wang, Liang Fang, Mengchao Qin, Tianxiao Zhao, Pingping Zhang, Hefei Xing, Yunping Xiao, Wende Liu, Qi Xie, Guo-Liang Wang, Yuese Ning (*). An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome. Genome Biology. 23: 154, 2022 、
Recommended in Faculty Opinions as New Finding and Technical Advance
22. Xiaoman You (#), Fan Zhang (#), Zheng Liu, Min Wang, Xiao Xu, Feng He, Debao Wang, Ruyi Wang, Yiqin Wang, Guirong Wang, Chengcai Chu, Guo-Liang Wang, Yuese Ning (*). Rice catalase OsCATC is degraded by E3 ligase APIP6 to negatively regulate immunity. Plant Physiology. 190: 1095–1099, 2022
23. Hong Fang(#), Fan Zhang (#), Chongyang Zhang, Dan Wang, Shuangqian Shen, Feng He, Hui Tao, Ruyi Wang, Min Wang, Debao Wang, XionglunLiu, Jie Luo, Guo-Liang Wang, Yuese Ning (*). Function of hydroxycinnamoyl transferases for the biosynthesis of phenolamides in rice resistance to Magnaporthe oryzae. Journal of Genetics and Genomics. 49: 776-786, 2022
24. Ruyi Wang (#), Xiao Xu (#), Guo-Liang Wang, Yuese Ning (*). Ubiquitination of susceptibility proteins modulates rice broad-spectrum resistance. Trends in Plant Science. 27: 322-324, 2022
25. Hong Fang (#), Shuangqian Shen(#), Dan Wang, Fan Zhang, Chongyang Zhang, ZixuanWang, Qianqian Zhou, Ruyi Wang, Hui Tao, Feng He, ChenkunYang, Meng Peng, Xinyu Jing, Zeyun Hao, XionglunLiu, Jie Luo (*),Guo-Liang Wang (*), Yuese Ning(*). A monocot- specific hydroxycinnamoylputrescine gene clustercontributes to immunity and cell death in rice. Science Bulletin. 66: 2381–2393, 2021
Featured on the cover
Highlighted with a Research Highlight article in Science Bulletin https://doi.org/10.1016/j.scib.2021.09.021
26. Ning Xiao (#),Cunhong Pan (#),Yuhong Li (#),Yunyu Wu,Yue Cai,Yue Lu, Ruyi Wang, Ling Yu,Wei Shi, Houxiang Kang,Zhaobing Zhu,Niansheng Huang,Xiaoxiang Zhang,Zichun Chen,Jianju Liu,Zefeng Yang (*), Yuese Ning(*), Aihong Li (*). Genomic insight into balancing high yield,good quality, and blast resistance ofjaponica rice. Genome Biology. 22:283, 2021
Highlighted with a Research Highlight article in Nature Food https://doi.org/10.1038/s43016-021-00410-w
27. Jiyang Wang (#), Ruyi Wang (#), Hong Fang, Chongyang Zhang, Fan Zhang, Zeyun Hao, Xiaoman You, Xuetao Shi, Chan Ho Park, Kangyu Hua, Feng He, Maria Bellizzi, Kieu Thi Xuan Vo, Jong-Seong Jeon, Yuese Ning (*),Guo-Liang Wang (*). Two VOZ transcription factors link an E3 ligase and an NLR immune receptor to modulate immunity in rice. Molecular Plant. 14: 253–266, 2021
28. Hui Tao, Xuetao Shi, Feng He, Dan Wang, Ning Xiao, Hong Fang, Ruyi Wang, Fan Zhang, Min Wang, Aihong Li, Xionglun Liu, Guo-Liang Wang (*),Yuese Ning (*). Engineering broad-spectrum disease-resistant rice by editing multiple susceptibility genes.Journal of IntegrativePlant Biology. 63:1639–1648, 2021
29. Chongyang Zhang, Hong Fang, Xuetao Shi, Feng He, Ruyi Wang, Jiangbo Fan, Pengfei Bai, Jiyang Wang, Chan Ho Park, Maria Bellizzi, Xueping Zhou, Guo-Liang Wang (*), Yuese Ning (*). A fungal effector and a rice NLR protein have antagonistic effects on a Bowman–Birk trypsin inhibitor. Plant Biotechnology Journal.18: 2354–2363, 2020
30. Ruyi Wang (#), Feng He (#), Yuese Ning (*),Guo-Liang Wang (*). Fine-Tuning of RBOH-Mediated ROS Signaling in Plant Immunity. Trends in Plant Science.25: 1060-1062, 2020
31. Yiwen Deng (#),Yuese Ning (#), Dong-Lei Yang (#), Keran Zhai, Guo-Liang Wang (*), Zuhua He (*). Molecular Basis of Disease Resistance and Perspectives on Breeding Strategies for Resistance Improvement in Crops. Molecular Plant. 13: 1402–1419, 2020
32. Xiaoman You (#), Hong Fang (#), Ruyi Wang (#), Guo-Liang Wang, Yuese Ning (*). Phenylalanine ammonia lyases mediate broad-spectrum resistance to pathogens and insect pests in plants. Science Bulletin. 65: 1425-1427, 2020
33. Wei Li (#), Yiwen Deng (#), Yuese Ning (#), Zuhua He (*), Guo-Liang Wang (*).Exploiting Broad-Spectrum Disease Resistance in Crops: From Molecular Dissection to Breeding.Annual Review of Plant Biology. 71:575–603, 2020
34. Ruyi Wang, Guo-Liang Wang (*),Yuese Ning (*).PALs: Emerging Key Players in Broad-Spectrum Disease Resistance. Trends in Plant Science. 24(9): 785-787, 2019
35. Chongyang Zhang (#), Zeyun Hao (#), Yuese Ning (*),Guo-Liang Wang (*).SINA E3 Ubiquitin Ligases: Versatile Moderators of Plant Growth and Stress Response. Molecular Plant. 12(5): 610-612, 2019
36. Yuese Ning, Guo-Liang Wang (*). Breeding plant broad-spectrum resistance without yield penalties. PNAS. 115(12):2859-2861, 2018
37. Feng He, Fan Zhang, Wenxian Sun,Yuese Ning (*), Guo-Liang Wang (*).A Versatile Vector Toolkit for Functional Analysis of Rice Genes. Rice. 11(1):27, 2018
38. Xuetao Shi (#), Yu Long (#), Feng He, Chongyang Zhang, Ruyi Wang, Ting Zhang, Wei Wu, Zeyun Hao, Yi Wang (*), Guo-Liang Wang (*), Yuese Ning (*). The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel. PLoS Pathogens. 14(1): e1006878, 2018
39. Yuese Ning, Wende Liu (*),Guo-Liang Wang (*). Balancing Immunity and Yield in Crop Plants. Trends in Plant Science. 22(12): 1069-1079, 2017
40. Qunen Liu (#),Yuese Ning (#), Yingxin Zhang (#), Ning Yu, Chunde Zhao, Xiaodeng Zhan,Weixun Wu, Daibo Chen,Xiangjin Wei, Guo-Liang Wang (*),Shihua Cheng (*), Liyong Cao (*). OsCUL3a Negatively Regulates Cell Death and Immunity by Degrading OsNPR1 in Rice. Plant Cell. 29(2): 345-359, 2017
41. Ruyi Wang (#),Yuese Ning (#), Xuetao Shi, Feng He, Chongyang Zhang, Jiangbo Fan, Nan Jiang, Yu Zhang, Ting Zhang, Yajun Hu, Maria Bellizzi, Guo-Liang Wang (*). Immunity to Rice Blast Disease by Suppression of Effector-Triggered Necrosis. Current Biology. 26: 2399–2411, 2016
Highlighted with a Dispatch article in Current Biology http://dx.doi.org/10.1016/j.cub.2016.08.038
42. Yuese Ning (#), Ruyi Wang (#), Xuetao Shi, Xueping Zhou, Guo-Liang Wang (*). A Layered Defense Strategy Mediated by Rice E3 Ubiquitin Ligases against Diverse Pathogens. Molecular Plant. 9:1096–1098, 2016
43. Yuese Ning (#), Xuetao Shi (#), Ruyi Wang (#), Jiangbo Fan, Chan Ho Park, Chongyang Zhang, Ting Zhang, Xinhao Ouyang, Shigui Li, Guo-Liang Wang (*). OsELF3-2, an ortholog of Arabidopsis ELF3, interacts with the E3 ligase APIP6 and negatively regulates immunity against Magnaporthe oryzae in rice. Molecular Plant. 8: 1679-1682, 2015
44. Hao Zhang, Jinling Liu, Feng He, Zhilong Wang, Yuese Ning (*), and Guo-Liang Wang(*). OsHUB1 and OsHUB2 interact with SPIN6and form homo- and hetero-dimers in rice. Plant Signaling & Behavior. 10:8, e1039212, 2015
45. Jinling Liu (#), Wei Li (#),Yuese Ning (#),Gautam Shirsekar,Yuhui Cai, Xuli Wang,Liangying Dai,Zhilong Wang,Wende Liu, Guo-Liang Wang (*). The U-box E3 Ligase SPL11/PUB13 Is a Convergence Point of Defense and Flowering Signaling in Plants. Plant Physiology. 160: 28-37, 2012
46. Yuese Ning,Chachawan Jantasuriyarat,Qingzhen Zhao,Huawei Zhang,Songbiao Chen,Jinling Liu,Lijing Liu,Sanyuan Tang, Chan Ho Park,Xuejun Wang, Xionglun Liu,Liangying Dai, Qi Xie (*),Guo-Liang Wang (*). The SINA E3 ligase OsDIS1 Negatively Regulates Drought Response in Rice. Plant Physiology. 157:242-255, 2011
