周焕斌，中国农业科学院研究员、博士生导师。

2000年、2003年先后于华中农业大学园艺林学学院获得蔬菜学学士与硕士学位，2007年于中国科学院遗传与发育生物学研究所获得遗传学博士学位。2007至2015年间，先后在美国加州大学河滨分校和爱荷华州立大学从事博士后研究。2015年起就职于中国农业科学院植物保护研究所。

现任中国农业科学院科技创新工程“抗病虫作物生态安全评价与利用创新团队”首席科学家，入选国家高层次人才特殊支持计划青年项目。主要学术兼职包括：中国遗传学会基因组编辑分会委员、中国作物学会分子育种分会委员、中国植物生理与分子生物学学会植物生物技术及其产业化分会委员、中国生物工程学会生物农业分会委员、中国植物保护学会生物安全专业委员会委员；同时担任BMC Plant Biology、Frontiers in Genome Editing副主编，Journal of Integrative Agriculture、aBIOTECH、植物病理学报及生物技术通报编委。

研究团队承担国家农业重大科技项目、农业生物育种重大项目、国家重点研发计划专项、国家自然科学基金面上项目等多项课题。研究方向聚焦于水稻抗性的人工设计与基因编辑利用，主要包括：1）微生物基因编辑工具开发与合成生物学研究；2）作物内源基因人工定向进化与抗性新材料挖掘；3）植物基因编辑技术体系与作物抗性合成生物学研究。团队致力于精准创制新型、广谱抗病和耐除草剂的水稻新种质，为我国农业绿色防控与可持续发展提供源头创新支撑。

目前已获得中国、日本授权发明专利共20项，在Molecular Plant、Cell Host & Microbe、The Plant Cell、Nucleic Acids Research、Journal of Advanced Research、Genome Biology、Plant Biotechnology Journal、Plant Communications、Plant Physiology、The Plant Journal、PLoS Pathogens等国内外高水平学术期刊上发表论文70余篇，其中7篇入选ESI高被引论文。

联系方式：zhouhuanbin@caas.cn

个人主页：https://www.researchgate.net/profile/Huanbin_Zhou

代表性论文（#通讯作者）

1. S Zhang, J Du, G Ma, C Yang, B Ren, F Yan, S Li, X Zhou & H Zhou^#. Efficient large-fragment isogenic sequence replacement in rice via prime editing with engineered reverse transcriptase variants. J Adv Res. 2026, accepted.

2. Z Xu, S Qiu, Y Tan, Y Kuang, C Yang, F Yan, X Zhou# & H Zhou^#. Optimized tRNA processing and TREX2-SpCas9 fusion enable high-efficiency multiplex genome editing in plants. Plant Commun. 2026, DOI: 10.1016/j.xplc.2026.101921.

3. M Yu & H Zhou^#. The Promise of base editing: Revolutionizing crop breeding through precise nucleotide changes. Plant Cell Environ. 2026, 49(2):1170-1173.

4. X Chen, X Yao, F Yan, S Li, Z Wang, F Yin, M Zhou, Z Wang, L Qin, B Zhao, K Lu, L Zhang, X Li, X Mu, Y Zhang, T Lu, J Ma, Y Zhao, D Lin, M Wang, Q Li, S Qi, J Long, B Bai, J Yu Ma, Y Liu, Y Feng, X Yang, J Zhang, Y Xu, L Chen, S Zou, X Ding, M Zhang#, D Yang#, Z Cheng#,  H Zhou^# & H Dong#. Alternative splicing of OsNPR3 promoted by bacterial TAL effectors-targeted splicing regulator OsRBP11 antagonizes OsNPR1 function to enhance disease susceptibility in rice. Mol Plant. 2025, 18(9):1505-1525.

5. X Li, S Zhang, C Wang, B Ren, F Yan, S Li, C Spetz, J Huang, X Zhou & H Zhou^#. Efficient in situ epitope tagging of rice genes by nuclease-mediated prime editing. Plant Cell. 2025, 37(2): koae316.

6. M Yu, Y Kuang, C Wang, X Wu, S Li, D Zhang, W Sun, X Zhou, B Ren^#, H Zhou^#. Diverse nucleotide substitutions in rice base editing mediated by novel TadA variants. Plant Commun. 2024, 8: 100926.

7. G Ma, F Yan, B Ren, Z Lu, H Xu, F Wu, S Li, D Wang, X Zhou & H Zhou^#. Targeted gene evolution by LbCas12a nuclease-mediated tiling deletion in non-coding regions. Plant Commun. 2024, 5(4): 100815.

8. M Wang, S Li, H Li, C Song, W Xie, S Zuo, X Zhou, C Zhou^#, Z Ji^# & H Zhou^#. Genome editing of a dominant resistance gene for broad-spectrum resistance to bacterial diseases in rice without growth penalty. Plant Biotechnol. J. 2024, 22: 529-531.

9. X Wu, B Ren, L Liu, S Qiu, X Li, P Li, F Yan, H Lin, X Zhou, D Zhang^# & H Zhou^#. Adenine base editor incorporating the N-methylpurine DNA glycosylase MPGv3 enables efficient A-to-K base editing in rice. Plant Commun. 2023: 100668.

10. F Yan, J Wang, S Zhang, Z Lu, S Li, Z Ji, C Song, G Chen, J Xu, J Feng, X Zhou & H Zhou^#. CRISPR/FnCas12a-mediated efficient multiplex and iterative genome editing in bacterial plant pathogens without donor DNA templates. PLoS Pathog. 2023, 19(1): e1010961.

11. S Li^#, C Wang, C You, X Zhou & H Zhou^#. T-LOC: A comprehensive tool to localize and characterize the T-DNA integration sites. Plant Physiol. 2022, 190(3):1628-1639.

Commented by G Alex Mason. T-LOCked in: Identifying T-DNA insertions in plant genomes. Plant Physiol. 2022, 190(3):1547-1549.

12. S Li^#, L Liu, W Sun, X Zhou & H Zhou^#. A large-scale genome and transcriptome sequencing analysis reveals the mutation landscapes induced by high-activity adenine base editors in plants. Genome Biol. 2022, 23: 51.

13. K Wang*, H Zhou* & Q Qian^#. The rice codebook: from reading to editing. Mol. Plant. 2022, 15: 569-572.

14. D Yan, B Ren, L Liu, F Yan, S Li, G Wang, W Sun, X Zhou & H Zhou^#. High-efficiency and multiplex adenine base editing in plants using new TadA variants. Mol. Plant. 2021, 14(5): 722-731.

15. Z Xu, Y Kuang, B Ren, D Yan, F Yan, C Spetz, W Sun, G Wang, X Zhou^# & H Zhou^#. SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition. Genome Biol. 2021, 22: 6.

16. L Liu, Y Kuang, F Yan, S Li, B Ren, G Gosavi, C Spetz, X Li, X Wang, X Zhou & H Zhou^#. Developing a novel artificial rice germplasm for dinitroaniline herbicide resistance by base editing of OsTubA2. Plant Biotech. J. 2021, 19(1): 5-7.

17. M Wang, Z Xu, G Gosavi, B Ren, Y Cao, Y Kuang, C Zhou, C Spetz, F Yan, X Zhou & H Zhou^#. Targeted base editing in rice with CRISPR/ScCas9 system. Plant Biotech. J. 2020, 18(8): 1645-1647. 

18. Y Kuang, S Li, B Ren, F Yan, C Spetz, X Li, X Zhou & H Zhou^#. Base-editing-mediated artificial evolution of OsALS1 in planta to develop novel herbicide-tolerant rice germplasms. Mol. Plant.  2020, 13(4): 565-572.

19. B Ren, L Liu, S Li, Y Kuang, J Wang, D Zhang, X Zhou, H Lin^# & H Zhou^#.  Cas9-NG greatly expands the targeting scope of the genome-editing toolkit by recognizing NG and other atypical PAMs in rice. Mol. Plant. 2019, 12(7): 1015-1026.

20. F Yan, Y Kuang, B Ren, J Wang, D Zhang, H Lin, B Yang, X Zhou & H Zhou^#. Highly efficient A·T to G·C base editing by Cas9n-guided tRNA adenosine deaminase in rice.Mol. Plant. 2018, 11(4): 631-634.

21. B Ren, F Yan, Y Kuang, N Li, D Zhang, X Zhou, H Lin^# & H Zhou^#. Improved base editor for efficiently inducing genetic variations in rice with CRISPR/Cas9-guided hyperactive hAID mutant. Mol. Plant. 2018, 11(4): 623-626.

22. B Ren, F Yan, Y Kuang, N Li, D Zhang, H Lin^# & H Zhou^#. A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice.Sci. China. Life Sci. 2017, 60(5): 516-519. （第二届中国科协优秀科技论文遴选计划入选论文）

23. H Zhou, B Liu, DP Weeks, MH Spalding & B Yang. Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice. Nucleic Acids Res. 2014, 42(17): 10903-10914.

24. H Zhou, J Lin, A Johnson, RL Morgan, W Zhong & W Ma. Pseudomonas syringae type III effector HopZ1 targets a host enzyme to suppress isoflavone biosynthesis and promote infection in soybean. Cell Host & Microbe. 2011, 9(3): 177-186. 

Commented by Andrew Bent. Pathogens Drop the Hint: Don't Forget Phytoalexin Pathways. Cell Host & Microbe. 2011, 9(3): 169-70.

25. H Zhou, RL Morgan, DS Guttman & W Ma. Allelic variants of the Pseudomonas syringae type III effector HopZ1 are differentially recognized by plant resistance systems. Mol. Plant Microbe Interact. 2009, 22(2): 176-189. 

26. H Zhou, S Li, Z Deng, X Wang, T Chen, J Zhang, S Chen, H Ling, A Zhang, D Wang & X Zhang. Molecular analysis of three new receptor-like kinase genes from hexaploid wheat and evidence for their participation in the wheat hypersensitive response to stripe rust fungus infection. Plant J. 2007, 52(3): 420-434.